Probiotic supplements may help improve symptoms of atopic dermatitis


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Disclosures: The authors do not report any relevant financial disclosures.

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Symptoms of atopic dermatitis improved in patients who received selected strains of probiotics, according to a study.

“The symptoms associated with AD are itching, redness, dry, scaly skin and recurrent eczematous lesions. The incidence of AD has increased worldwide over the past decades and affects 60% of the population, especially children. Angela Michelotti, MD, and his colleagues wrote. “The gut microbiome can strongly influence the host’s immune system, providing protection against pathogens and triggering a protective immune response.”

The single-center, randomized, double-blind, placebo-controlled, parallel-group study included 80 patients with mild to moderate AD who were assigned 1: 1 to an active group or to a placebo group.

The active group received a dietary supplement containing a 1 × 10 probiotic mixture9 UFC L. plantarum PBS067, 1 × 109 UFC L. reuteri PBS072 and 1 × 109 UFC L. rhamnosus LRH020, 26 mg of corn starch and 1 mg of vegetable magnesium stearate, while the placebo group received a daily capsule of 99 mg of corn starch and 1 mg of vegetable magnesium stearate.

The atopic dermatitis SCORing index (SCORAD) improved in both groups; however, the supplement group experienced a significant and gradual decrease in the SCORAD index, which continued for 1 month after stopping.

The skin softness and hydration indices were also significantly improved in the treatment group.

Additionally, skin tightness had a positive response of 90% in the treatment group.

“Providing probiotics in AD is an interesting intervention because it does not address the symptoms, but rather the cause of the disease (intestinal dysbiosis),” the authors wrote. “Thus, a more effective and lasting overall improvement can be achieved, as indicated in this clinical trial.”

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